Allosteric modulatory effects of SRI-20041 and SRI-30827 on copyright and HIV-1 Tat protein binding to human dopamine transporter
Abstract Dopamine transporter (DAT) Spark Plugs is the target of copyright and HIV-1 transactivator of transcription (Tat) protein.Identifying allosteric modulatory molecules with potential attenuation of copyright and Tat binding to DAT are of great scientific and clinical interest.We demonstrated that tyrosine 470 and 88 act as functional recogni